Abstract: Document-level relation extraction aims to extract relations among entities within a document. Different from sentence-level relation extraction, it requires reasoning over multiple sentences across paragraphs. In this paper, we propose Graph Aggregation-and-Inference Network (GAIN), a method to recognize such relations for long paragraphs. GAIN constructs two graphs, a heterogeneous mention-level graph (MG) and an entity-level graph (EG). The former captures complex interaction among different mentions and the latter aggregates mentions underlying for the same entities. Based on the graphs we propose a novel path reasoning mechanism to infer relations between entities. Experiments on the public dataset, DocRED, show GAIN achieves a significant performance improvement (2.85 on F1) over the previous state-of-the-art. Our code is available at https://github.com/PKUnlp-icler/GAIN.