Abstract: Distant supervision (DS) has been widely adopted to generate auto-labeled data for sentence-level relation extraction (RE) and achieved great results. However, the existing success of DS cannot be directly transferred to more challenging document-level relation extraction (DocRE), as the inevitable noise caused by DS may be even multiplied in documents and significantly harm the performance of RE. To alleviate this issue, we propose a novel pre-trained model for DocRE, which de-emphasize noisy DS data via multiple pre-training tasks. The experimental results on the large-scale DocRE benchmark show that our model can capture useful information from noisy data and achieve promising results.