Abstract: The need for the annotated training dataset on which data-hungry machine learning algorithms feed has increased dramatically with advanced acclaim of machine learning applications. To annotate the data, people with domain expertise are needed, but they are seldom available and expensive to hire. This has lead to the thriving of crowdsourcing platforms such as Amazon Mechanical Turk (AMT). However, the annotations provided by one worker cannot be used directly to train the model due to the lack of expertise. Existing literature in annotation aggregation focuses on binary and multi-choice problems. In contrast, little work has been done on complex tasks such as sequence labeling with imbalanced classes, a ubiquitous task in Natural Language Processing (NLP), and Bio-Informatics. We propose OptSLA, an Optimization-based Sequential Label Aggregation method, that jointly considers the characteristics of sequential labeling tasks, workers reliabilities, and advanced deep learning techniques to conquer the challenge. We evaluate our model on crowdsourced data for named entity recognition task. Our results show that the proposed OptSLA outperforms the state-of-the-art aggregation methods, and the results are easier to interpret.